线粒体呼吸能力和膜电位的改变：线粒体失调与自闭症之间的联系

Alterations in mitochondrial respiratory capacity and membrane

potential: a link between mitochondrialdysregulation and autism

Keywords：autism spectrum disorders, oxidative phosphorylation, cytochrome c oxidase activity, mitochondrial membrane potential, mitochondrial disease 

关键词：自闭症谱系障碍、氧化磷酸化、细胞色素c、氧化酶活性、线粒体膜电位、线粒体疾病
作者：Hassan Hazirah、Gnaiger Erich、Zakaria Fazaine、Makpol Suzana、Abdul Karim Norwahidah

出版期刊：《Mito Fit Preprint Arch》（2020年）

Abstract：

Mitochondrial dysfunction has been implicated in the pathogenesis of autism. We compared mitochondrial respiratory control in autism with normal lymphoblastoid cell line and found that the oxidative phosphorylation and electron transfer of the NADH- and succinate-linked pathways, and cytochrome c oxidase activity of the autism lymphoblastoid cell line were higher. Mitochondrial membrane potential was also higher in the succinate-pathway during LEAK respiration and oxidative phosphorylation. Taken together, these results indicate abnormalities in mitochondrial function with autism. Understanding the link between mitochondrial dysfunction and autism is important for early and effective interventions.

文章摘要：

线粒体功能障碍与自闭症的发病机制有关。 我们将自闭症中的线粒体与正常的类淋巴母细胞系进行比较，发现自闭症类淋巴母细胞系的 NADH 和琥珀酸相关途径的氧化磷酸化和电子转移以及细胞色素 c 氧化酶活性更高。 在泄漏呼吸和氧化磷酸化过程中，琥珀酸通路中的线粒体膜电位也较高。 总之，这些结果表明自闭症线粒体功能异常。 因此了解线粒体功能障碍与自闭症之间的联系对于早期有效的干预非常重要。

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